Russia has been suspicious of most US actions fearing they are directed against Russia. This suspicion is in part born out of the cold war, Russia is much weaker than the USSR was and is worried about any US expansionism. The expansion of NATO to include former Soviet states such as Lithuania has resulted in one Russian news organisation declaring "Generations of Russians feel betrayed by NATO's expansion."[1] The United States’ missile defence proposals have been a continuing sore in relations. In 2007 then President Putin compared the proposed siting of anti-ballistic missile systems in Eastern Europe with the Cuban Missile Crisis, “The situation is quite similar technologically for us. We have withdrawn the remains of bases from Vietnam and Cuba, but such threats are being created near our borders.”[2] It is clear from this that Russia will not be able to cooperate with many things that the United States considered to necessary. Things like NATO expansion and missile defense which the United States considers to be defensive Russia believes are aimed at Russia, either to encircle it or to negate Russia’s main strategic asset; its nuclear arsenal.

Contradictions between Russian and U.S. interests will always exist. The United States is not Russia's ally, and it can be confidently predicted that it never will be. While politically the two countries sometimes temporarily need each other to face global challenges, as long as it does not harm them politically or economically, militarily they will remain positioned as strategic enemies. NATO is a good example of this. While the United States believes NATO brings peace and stability Russia feels directly threatened by NATO expansion into states that were once a part of the Soviet Union such as the Baltic states or the possibility of expansion to Ukraine or Georgia.[1] There have even been suggestions that Russia’s 2008 conflict with Georgia was to prevent Georgia proceeding down the path to NATO membership with US encouragement. A view partially substantiated by President Putin himself “it has become absolutely clear that the desire of Georgian authorities to join NATO is motivated not by their ambition to form part of a global security system and contribute to the strengthening of international peace. Tbilisi's NATO bid is determined by other considerations, namely an attempt to embroil other nations in its bloody undertakings… from a legal point of view, Russia's actions in South Ossetia are totally legitimate.”[2] As a result America's relations with Russia will never resemble its relations with France or Great Britain. U.S. strategic nuclear planning will always envisage a potential Russian nuclear attack on targets on American territory. Likewise, Russian planners will not rule out an American attack on Russian targets.

Russia and the US have a fundamental divergence over the notion of spheres of interest. Russia only accepts any other country playing a role in its near abroad very grudgingly and will attempt to get other great powers out whenever possible. In the aftermath of 9/11 Russia could not prevent American intervention in Central Asia therefore it was sensible to make sure it was co-opted to serve Russia’s own interests, namely to be against international terrorism, rather than being directed against Russia herself. By doing so Russia could preserve her influence in the region. As America was willing to take on the costs of maintaining the security of the region Russia could retrench and cut costs.[1] Yet Russia began to force the US out as soon as was possible, for example forcing the closure of a U.S. airbase in Kyrgyzstan.[2]

Russia has sometimes seemed to purposefully take the opposite side to the US in Eastern Europe. An example of this occurring was over the possibility of independence for Kosovo almost a decade after the conflict that forced Serbian forces out of the country. According to Charles Kupchan “on the question of Kosovo, direct Russian interests are difficult to discern, and therefore it appears that Russia’s backing of Serbia is part of a more muscular Russian policy, and a desire to stand up to the United States and the EU across the board.”[3]

Good economic relations are possible only as long as long as The USA believes that Russia is genuinely trying hard to bring its economy into line with the Western world. Both Putin and Medvedev have emphasised that the country’s economic interests will always determine Russian foreign policy. Most particularly foreign policy has been driven by oil and natural gas. This has involved a conflict with the United States over the construction of pipelines. The Baku-Tbilisi-Ceyhan (BTC) oil and the Baku-Tbilisi-Erzurum (BTE) gas pipelines are specifically built to diversify European energy supplies away from dependence on Russia but were only built due to unequivocal US support.[1] Building these pipelines is directly against Russian interests. Russian economic interests include, amongst other things, close trade links with autocratic regimes, particularly in the former USSR, and exporting weapons and nuclear technology to China and Iran. In the example of Iran Russian economic interests have meant that Russia has blocked US efforts to get sanctions.[2] An area of particular conflict with the US is the Russian building of an $800million nuclear reactor at Bushehr. Similarly Russia sold Iran $1.7 billion of arms between 2002 and 2005 including anti-aircraft systems so making any potential attack on Iranian nuclear facilities by the United States much more dangerous.[3] Thus, close economic cooperation between two states whose economies are driven by very different goals is improbable.